Andrew Lenhardt, MD

Personalized Medicine

  • Athletic Performance

    Athletic Performance

     

    A. Key Elements

    1. Magnesium and mineral supplementation
    2. Infrared Sauna
    3. High Intensity Interval Training (HIIT)

     

    B. Mainstream

    • Work-up beyond a history and physical: None.
    • Mainstream treatments: None.

     

    C. Resources

     

    E. Testing Options

    1. Hair Tissue Mineral Analysis (HTMA)
    2. VO2 Max assessment
    3. Labs including RBC magnesium, RBC zinc, CBC, BMP, TSH, free T3, free T4 and fasting cortisol
    4. Urine for Organic Acids

     

    F. Regimen

    1. Supplements: Concentrace mineral tablets (or ionic liquid) or 40,000 volts minerals or Aussie Minerals or Nutrient 950 and/or magnesium malate based on test results and individual factors but more vigorous exercise in general equals higher demands for magnesium and other minerals.
    2. Hyperthermic Conditioning through Infrared Sauna:
      1. Increases conditioning by increases nutrient delivery to muscles so that they are not as dependent on glycogen storage.;
      2. Improves muscle hypertrophy;
      3. Increases heat shock proteins;
      4. Induces release of growth hormone (GH); and
      5. Improves insulin sensitivity
    3. HIIT
  • Attention Deficit Disorder (ADD/ADHD)

    Attention Deficit Disorder (ADD/ADHD)

     

    A. Key Elements

    1. Sleep: Need adequate quantity and quality of sleep and avoidance of electronic in the evening especially within an hour of bedtime.
    2. Gastrointestinal health, food sensitivities and the microbiome
    3. Nutrition, mineral deficiencies and dietary change including avoidance of wheat, dairy and processed foods as much as possible
    4. Detoxification: three toxins probably implicated in the majority of ADD/ADHD cases including polychlorinated biphenyls (PCBs), PBDEs (flame retardant chemicals) and polycyclic aromatic hydrocarbon compounds (PAHs)
    5. Full work-up for hearing problems, sensory integration dysfunction, learning disabilities, mood disorders and other before diagnosis of ADD/ADHD is made.
    6. Executive Functioning Problems
    7. Limbic System Dysfunction

     

    B. Mainstream

    • Work-up beyond history and physical: None except ADD/ADHD questionnaires.
    • Treatments: pharmaceutical via stimulants like Adderall, Concerta and Ritalin or a non-stimulant Strattera.

     

    C. Resources

     

    D. Testing Options (in no particular order):

    1. IgG or other food sensitivity testing like FIT test from KRBO, Great Plains Labs, Doctor’s Data Lab and others
    2. Hair Tissue Mineral Analysis (HTMA) especially to check for mineral deficiencies and imbalances
    3. GPL-TOX lab test especially to check for PCBs, PBDEs and PAHs
    4. Urine for OAT
    5. Sleep study
    6. Neuropsychological Testing to check for other contributing aspects like mood disorders, dyslexia, learning disabilities, sensory integration dysfunction, auditory processing, visual processing
    7. Hearing Test

     

    E. Options for Treatment/Management/Prevention:

     

    • See below.  Work-up is important early on to rule out hearing problems and auditory/visual processing difficulties as part of sensory integration dysfunction.   Testing through school system encouraged.
    • Foundation is dietary change, limited electronics especially before sleep, sleep quality, supplements like Omegas, minerals, bulletproof coffee or unicorn fuel coffee, probiotics plus individualize options based on toxic load, testing and subtypes per Amen book above.
    • Infrared sauna (Rhonda Patrick Youtube video.)  Infrared sauna helps focus by increasing release and storage of norepinephrine and increases prolactin that helps brain function faster through myelination plus increase BDNF that increases growth of new brain cells and decreases depression and anxiety.
    • Active Healing in North Beverly has a number of modalities that can help children with focus problems including infrared sauna.

     

    F. References and Notes:

    1. From Brainmaker book: Half of ADHD kids have hypersensitivity to dairy, wheat, processed foods, etc.  GABA is deficient in the brains of ADHD kids. GABA comes from glutamine and the cofactors zinc and B6.  Lactobacillus and bifidobacterium produce GABA in abundance.  2003 study: 20 kids with ADHD. ½ Ritalin and ½ l. acidophilus plus omegas – equal outcomes.
    2. From Daniel Amen book: 1. Eliminate toxic substances, 2. Protect your head, 3. Diet, 4. Exercise, 5. Avoid prolonged computer games, 6. Sleep, 7. Neurofeedback, 8. Omegas.
      1. Type 1 Classic ADD: hyperactive, restless, impulsive, easily distracted, disorganized. Treatment: Basics plus stimulants plus L-tyrosine and variety of stimulating herbs potentially. High protein, high good fat and low simple carb diet enhances focus.
      2. Type 2 Inattentive ADD: easily distracted, disorganized, space cadets, daydreamers or cough potatoes.  Treatment: Similar to above plus mineral support and evaluation for executive functioning problems.
      3. For Type 3 Overfocused ADD: (chapter 8) trouble shifting attention; get stuck in loops of negative thoughts or behaviors; can be obsessive, worried and inflexible; frequently oppositional, argumentative and fault finding. Treatment: St. John’s Wort 300mg once daily for kids, 300mg twice a day for teens, 600/300 adults; L-tyrosine 100-500mg twice a day for kids, 500-1500 twice a day for adults but not alone as it would increase hyperfocus; stimulants; 5-HTP if depressed mood 50-300mg daily for adults, half that dose for kids. Since often have deficiency of serotonin or dopamine or both, so Effexor/Cymbalta better than SSRIs.
      4. Temporal Lobe ADD: ADD core symptoms plus learning and behavioral problems with mood instability, irritability, dysplexia and memory problems. Can have auditory processing issues, periods of quick temper, periods of spaciness, panic or fear with no obvious reason, déjà vu, sensitivity or mild paranoia, headaches/abd pain of uncertain cause, sometimes from TBI, occ. dark thoughts. Treatment: Mood stabilizer (Lamictal or Depakote or gabapentin) and stimulants.  Stimulants alone will often make people worse with more irritability and more aggression.  Consider GABA. 100-500mg daily (1/2 of the dose for kids), magnesium and see p. 262 for others.
      5. Limbic ADD: ADD core plus moodiness, negativity, low energy, tendency to be socially isolated, anhedonia, sleep changes, low self-esteem. Differentiate depression alone because that tends to be cyclic.  Treatment: DL-phenylalanine and L-tyrosine, the amino acid building blocks for norepinephrine and dopamine plus intense exercise and diet changes. SSRIs can make people worse. Can use Wellbutrin and stimulants also. Consider DLPA DL-phenylalanine 400mg three times a day for adults and 200mg three times a day for kids; L-tyrosine and SAMe.
      6. Ring of Fire ADD: sensitivity to noise, light, clothes or touch; cyclic mood changes; inflexible; demanding to have their way even if told no multiple times and oppositional behavior; periods of increased talkativeness/hyperverbal; periods of mean/nasty behavior; unpredictable; can be grandiose or appear manic; Treatment: Stimulants can make things worse.  SSRIs and St John’s Wort can make them worse. Elimination diet, GABA, 5-HTP, L-tyrosine can help and sometimes Depakote.  No SAMe (p264) because can trigger mania.
      7. Anxious ADD: anxious/stressed, headaches, freeze in social situations, predicts the worst, conflict avoidant, fear of being judged. Treatment: relaxation, exercise, magnesium, L-theanine and potentially low dose stimulants.

     

    Toxin Notes:

    1. PCBs: Polychlorinated biphenyls were once widely deployed as dielectric and coolant fluids in electrical apparatus, carbonless copy paper and in heat transfer fluids.
    2. PBDE: organobromine compounds used as flame retardants.
    3. PAH: Found in coal and tar deposits.
  • Autism

    A. Key Elements

    1. Toxins and Detoxification: mercury, other heavy metals, bromine, others

    2. Gastrointestinal Health: including food sensitivities, dysbiosis, intestinal permeability, small intestinal bacterial overgrowth (SIBO) and the microbiome.

    3. Nutrition: Vitamin and mineral deficiencies with avoidance of proinflammatory foods  (like gluten, wheat, dairy and sugar) and emphasis on nutrient-dense foods.

    4. Sleep: quality and quantity

    5. Immune dysfunction

    6. Methylation cycle anomalies: MTHFR, COMT, CBS and others.

    7. Avoidance of acetaminophen, antibiotics and steroids whenever possible

    8. Preventative strategies through prepregnancy and pregnancy planning

     

     

    B. Mainstream Approach

     

    Mainstream work-up beyond history and physical: None

     

    Mainstream treatments: ABA therapy, Occupational Therapy

     

     

    C. Resources

    • Pathways to Recovery by Amy Yasko, ND, PhD
    • The Autism Research Institute at autism.com
    • The Autistic Brain: Helping Different Kinds of Minds Succeed by Temple Grandin and Richard Panek
    • The Best of All Worlds case studies and prepregnancy planning protocol at drlenhardt.com by Andrew Lenhardt, MD

     

     

    D. Testing Options

     

    1. Hair Tissue Mineral Analysis (HTMA) especially to check for mineral deficiencies and imbalances

    2. Methylation cycle SNP analysis through 23andme and then geneticgenie.org, livewello.com or mthfrsupport.com

    3. Urine for Organic Acids Test that assesses for:

    a. General vitamin and mineral deficiencies/insufficiencies

    b. Amino acid insufficiencies like carnitine and N-acetyl cysteine (NAC)

    c. Oxidative damage and antioxidant sufficiency markers

    d. Indicators to assess effectiveness of endogenous detoxification

    e. Best functional markers of B-vitamin deficiencies

    f.  Neurotransmitter metabolites to assess central nervous system (CNS) function

    g. Mitochondrial energy production assessment via citric acid cycle components

    h. Methylation sufficiency status

    i. Lipoic acid and CoQ10 sufficiency markers

    j. Specific dysbiosis markers for bacterial and yeast overgrowth

    4. Blood Tests: homocysteine, folate, B12, RBC zinc, others

    5. Comprehensive Stool Analysis with Parasitology from Great Plains Labs (or other outside labs) especially to look for diversity of bacteria and presence of Clostridia species

    6. Nasal/sinus culture from Microbiology Dx Lab

    7. IgG or other food sensitivity testing like Cyrex, FIT test from KRBO, Great Plains Labs, Doctor’s Data Lab and other

     

     

    E. Options for Treatment/Management/Prevention

     

    1. detoxification by a variety of means including intranasal glutathione.

    2. probiotics like Dr. Ohhira, Megafood by Megaflora (with an option designed for children with autism that is gluten free, casein free), Prescript Assist and many others

    3. nutrient supplements especially based on lab testing and methylation cycle analysis.  Curcumin binds ribosomal sites and lowers CNS inflammation, preventing plaque formation.  Omega-3 fatty acids, NAC

    4. dietary modifications generally (no wheat/gluten, no dairy) or based on specific food sensitivity testing

    5. nasal probiotic rinses and/or nasal antibiotics targeted to resistant bacteria.

    6. Restore, Bovine Collostrum, L-glutamine, Aloe Vera Juice, Cabbage Juice and others to help with gut integrity and tight junctions.

     

     

    F. References and Notes

     

    1. From Brainmaker by David Perlmutter: In Autism, can see high LPS in blood, higher levels of clostridia species with relatively low bifidobacteria and clostridia leads to carb cravings.  In one study, kids with autism had 9 species of clostridia not found in controls.  PPA into bloodstream from clostridia likely plays role and is toxic to the brain.  PPA increases inflammation, increases gut permeability, affects cell-to-cell signaling, compromises mitochondrial function, increases oxidative stress and depletes brain of antioxidants, neurotransmitters and omega 3s.  Treatment can be l-carnitine, omega 3s, NAC to increase glutathione production plus probiotics.

     

    2. Small intestinal bacterial overgrowth (SIBO) causes increased levels of LPS/endotoxin (increases brain sensitivity via direct activation of NMDA receptors; increased perception of pain; impaired mitochondrial function and cytokine release), hydrogen sulfide and D-lactic acid (a neurotoxin and metabolic poison)

     

    SIBO leads to malabsorption and nutrient deficiencies including vitamin D and magnesium that can worse chronic pain.

     

    SIBO can lead to low L-tryptophan levels because of increased activity of bacterial tryptophanase.  FM patients produce 31% less melatonin affecting sleep and pain perception.  Lower 5-HTP leads to lower serotonin which can lead to more pain, depression, anxiety and food/cho cravings.  FM patients have low tryptophan proportional to level of pain 50-300mg/day.

     

    SIBO treatments: probiotics, vegetarian/paleo diet, vitamin A, zinc, L-glutamine plus antibiotics like rifaximin, cipro, augmenting, flagyl and/or berberine, artemisia, peppermint oil and oil of oregano and/or amino acid supplements, CoQ10 100mg three times a day, gingko 200mg daily?

     

    Each step of mitochondrial electron transport chain requires specific nutrients to generate ATP: complex 1 needs B2, B3 and CoQ10; complex 2 requires B2, iron, DHA and CoQ10; complex 3 requires iron; complex 4 requires vitamin C and copper.

     

    Would prefer to use Urine for OAT test to individualize therapies for SIBO, mitochondrial dysfunction, vitamin and mineral deficiencies and other aspects.

  • Cancer Prevention and Adjunctive Treatments

    Cancer Prevention and Adjunctive Treatments

     

     

    A. Key Elements:

    1. Toxic Load and Detoxification
    2. Diet and Nutrition
    3. Immune Support
    4. Chronic Parasites
    5. Psychosocial Factors
    6. Occupational Exposures

     

     

    B. Mainstream work-up beyond a history and physical: extensive including pap smears, colonoscopy and mammogram for prevention with many lab tests and imaging studies used for diagnosis and management

     

    Mainstream treatments: surgery, radiation and chemotherapy

     

     

    C. Resources

     

    D. Testing Options

    1. Extensive laboratory options.
    2. Specialized tests as reviewed below under the Cancer Free section.
    3. Urine and stool testing for chronic parasites through Parawellness.
    4. Genetic analysis including methylation cycle testing, assessment of detoxification pathways and tendencies to specific cancer types
    5. Urine for organic acids (OAT) through Genova, Great Plains and other labs

     

     

    E. Options for Treatment/Management/Prevention:

    • Caveat: Most or all of these treatments are speculative and have not been rigorously tested in a double-blind, placebo-controlled fashion. With many natural options, however, that is not possible. How could we placebo-control dietary and nutritional changes? Also, with integrative approaches, it is almost always the synergistic effects of many interventions that likely produces the greatest benefit. It is not practical to test each variable for benefit against placebo in a complex system like the human body.

     

    • Potential Cancer Protocol:
    1. Annual starting at 40 years old, do the AMAS blood test (or the urine hcg or both).  If positive result, consider HRB, Oncoblot and others tests for confirmation and clarification.
    2. Women start thermography in 40s depending on risk factors +/- mammogram +/- breast MRI plus Pap every 3 years and colonscopy depending on a wide variety of factors.
    3. For those with positive screening tests, do follow-up testing as needed and start an individualized protocol based on the following:

     

    • Primary:
    1. no sugar, wheat, grains or alcohol.
    2. Alkalinize the body with alkaline water, lemon water (in glass containers so do not leach out chemicals from plastic) more raw fruits and vegetables and less animal protein.
    3. Abundant organic fruits, vegetables and other foods with high nutrient-density.
    4. Find an advocate who will come to all visits and help with research, protocols and treatments.
    5. Consider Parawellness testing for parasites and/or treatment with Energetix Para V Core with black walnut hull, wormwood and clove oil at 30 drops in water twice a day for 5-7 days.
    6. Detoxification and Cleansing with many options as reviewed below.

     

    • And consider in addition to the primary approaches:

    1. GcMAF: a company developed a yogurt of all things where the bacteria make high amounts of this substance that helps the immune system take out viruses and cancer cells. Visit their website, yogurt can be made at home.

     

    Recommended to have Bravo yogurt after a main meal of protein and leafy greens, hold in mouth and swish around 10-30 seconds to allow the GcMAF to pass through sublingually, swallow and don’t rinse out the mouth for at least 30 minutes.  Start at 5ml per day increasing by 5ml per day up to 100ml per day. $80 for 1L kit to make yourself.

     

    2. Salvestrol: Get the Salvestrol Platinum starting at one breakfast and lunch and work up to two with breakfast and one at lunch. This options works best with certain "co-factors" so best to eat organic fruits and vegetables and I would potentially order the O.N.E. multivitamin from Pure Encapsulations to take daily.

     

    3. Gerson approach: Full Gerson is 5 coffee enemas at 6am, 10am, 2pm, 6pm and 10pm plus 8oz juice every hour 13 times during the day plus lugol 3 drops six times a day, thyroid supplement, niacin, pancreatin and liver caps 3-6 times a day each.

     

    Modified Gerson (Lenhardt variation) would substitute glutathione (as suppositories or nasal spray or topical cream) for the coffee enemas plus 20 oz. juice three times a day (1 citrus, 1 carrot/apple and 1 green) plus potentially other supplements like iodoral/i-throid once a day, Nutrient 950, others with strict diet of no processed foods, no processed sugar, no wheat, no gluten and no dairy.

     

    From Appendix of Gerson book with details on preparation:

    • Citrus Juice: use reamer-type juicer. Don’t use skin. Oranges, lemons and/or limes.
    • Apple/Carrot: equal proportion. Wash, do not peel. Don’t use core. Can be kept in thermos for 2-3 hours.
    • Green Leaf Juice: use up to 3 or more of escarole, endive, romaine, lettuce, red lettuce, beet tops, watercress, swiss chard, green pepper and/or red cabbage (2-3 leaves) and add 1 apple per glass. Drink immediately.

     

    4. Budwig Diet: This is a combination of flaxseed oil and cottage cheese that has been shown to kill cancer cells (especially if stop all hydrogenated fats). Mix 6 ounces (2/3 cup) of organic cottage cheese with 6 tbsp of flaxseed oil (1/3 cup) every day as quickly as possible using immersion blender, let sit 5-8 minutes and can put in blender with berries, water, almond milk, nuts. Need to keep oil in refrigerator. For more information, visit the Budgwig Center's website or phone Barlean's 800-445-3529.

     

    5. IV vitamin C therapy: Atsuo Yanagisawa, MD, PhD, of the Japanese College of Intravenous Therapy, explains the powerful non-invasive benefits of IV vitamin C therapy for cancer in Japan's version of NEWSWEEK. Here are some excerpts from the interview:

    •  “When there is a high concentration of vitamin C in the blood, the constituents seep out of blood vessels, creating hydrogen peroxide (reactive oxygen), which, once taken in by cancer cells, greatly arrests the activity of the cancer.” (Note: healthy cells remain healthy in this process.
    •  “Apart from some extremely rare types of cancer, we know that high-dose IV vitamin C therapy is very effective against just about all forms of cancer
    • “In illnesses where progression is fast, like pancreatic cancer, an IV infusion needs to be given on consecutive days, whereas, with slow progression cancers, like prostate cancer, the basic rule is to just administer the vitamin C about once a week. So, frequency and amount of therapy needs to be adjusted while giving consideration to degree of progression and the stage reached.”

     

    Dr. Yanagisawa says, "The vitamin C used in this treatment is highly concentrated and is given in 50- to 100-gram doses, which is the equivalent to 2,000 to 5,000 lemons directly introduced into a vein directly. Oral vitamin C cannot achieve the same systemic concentration levels as IV vitamin C. With research becoming more available, more and more physicians in the USA are using a combination of chemotherapy and high-dose IV vitamin C therapy to improve patient outcomes."

     

    North Coast Family Health Integrative Medicine Clinic in Portsmouth, NH at 603-427-6800 may be a local group to help with IV vitamin C and other therapies.

     

    • Other supplements to consider for prevention and treatment:
    1. iodine to reduce risk of hormonal/glandular tumors like breast in particular and bromine avoidance.  Iodine deficiency common (up to 95% of women based on the work of David Brownstein).
    2. Zinc to reduce risk of prostate cancer (either after zinc taste test or RBC zinc level).  Zinc deficiency is common and low alkaline phosphatase can reflect zinc deficiency.  Can use "zinc taste test" since zinc is responsible for our sense of taste. If drink zinc solution, should taste like dirty metal but if it tastes okay the person is probably zinc deficient.  (eggs, wheat germ high in zinc)
    3. MSM
    4. Vitamin D to get serum level over 50
    5. THC/CBD in different forms from different strains
    6. Hoxsey Tonic

     

     

    Cancer Free book by Bill Henderson notes

     

    Cancer cells look unusual to the immune system because they have lost their ability to utilize oxygen. Instead, they use fermentation of fructose and glucose for energy with 17 times the receptors for glucose compared to a normal cell.

     

    Cancer cells usually travel to the weakest and most acidic organ in your body and the tumor is nurtured. 90% of cancers involve tumors but leukemia, lymphoma and melanoma and others do not.

     

    Avoid any “procedure” that might cause the spread of tumor cells. With Chapter 5 regimen, he says it will bring almost all cancers under control within a few weeks if no surgery, chemo or XRT is done.

     

    Cigarettes produce largest number of free radicals. Bad fats correlate with free radical production especially trans-fatty acids, e.g. french fries. Many of the antioxidants needed to take out free radicals come from supplements. Best might be the Daily Advantage supplement, one package with breakfast and second with lunch or dinner. And second most important supplement according to Bill Henderson is the Ultra-Fit from Dr. Joe Davis.

     

    Conventional cancer treatments destroy the immune system. Cancer typically returns with resistance to chemotherapy. Chemotherapy wipes out the lining of the intestines leading to malabsorption and progressive nutrient deficiencies when nutrients are needed most.

     

    There are a few malignancies that are responsive to chemotherapy including: Burkitt’s lymphoma, choriocarcinoma, ALL, Hodgkin’s Disease, lymphosarcoma, Wilms Tumor, Rhabdomyosarcoma. Says chemotherapy is effective in less than 2% of breast cancer patients.

     

    Root canal-filled teeth might be the direct cause of many cancers. Source of toxins from bad teeth are anaerobic bacteria that fill in any gaps and tubules because circulation has been cut off to the tooth.

     

    Mercury-amalgam fillings with silver, tin, copper and zinc and 51% mercury. For more information, visit Holistic Healing page for more information about fillings. Fillings need to be removed by qualified holistic dentists [like Groton Wellness] and can check International Academy of Biological Dentistry & Medicine (IABDM) website. Possibly get IV vitamin treatment before the process.

     

    Tests (with * for those most essential):

    1.  Trace Mineral Test from Metatrix at $150
    2. Natural Killer Cell Activity Test from Quest (code #1872) at $124
    3. Anti-Malignin Antibody in Serum (AMAS) Test that can detect cancer nearly two years before any other method with accuracy above 99% and can detect recurrence of cancer. Covered by Medicare. From Dr. Bogoch’s Oncolab, 800-922-8378 for $165. Test is unreliable for advanced cancers and some false negatives particularly for breast cancer.
    4. * HCG Urine Test: This is probably the best of all [according to the author]. Recommended to do it every two months for those diagnosed with cancer. Alternative to AMAS Test. Test tells the relative number of abnormally dividing cells. > 50 with cancer diagnosis, shows level of cancer cells in the body. < 50 is normal result. Cost is $55 through Navarro Clinic. For number > 50, start treatment and monitor. Use soon after cancer diagnosis as a baseline.
    5. *Parasite Testing: Strong correlation with parasites and cancer.  Yeast and parasites with toxins suppress the immune system.  Test is through the Parawellness, ($297), 303.680.2288.
    6. *Live blood cell analysis recommended every month.

     

    Treatments:

    1. Beta-13D Glucan (from AJ): binds to receptor on cancer cells triggering a response by NK cells and immune system. Take dose based on body weight once a day on empty stomach.  Best might be from Transfer Point or Health co-op version of beta glucan. Avoid NSAIDs and aspirin if taking. Immune boosters to insurance that the cancer does not recur. BH says immune boosing is PRIORITY ONE.
    2. MGN-3 for immune support.
    3. Vitamin D: “To heal cancer, you have to elevate the vitamin D level in your blood and keep it high forvever.” Recommends starting with 25,000 IU daily and then want to maintain a level 70 or higher probably needing 10,000 IU daily as D3.
    4. Barley Power Pills
    5. Paw Paw for multiple drug resistant (MDR) cells leftover from chemotherapy. One four times a day with food from Nature’s Sunshine.
    6. Budwig Diet: combination of flaxseed oil and cottage cheese kills cancer cells (especially if stop all hydrogenated fats). Mix 6 ounces (2/3 cup) of organic cottage cheese with 6 tbsp of flaxseed oil (1/3 cup) every day as quickly as possible using immersion blender, let sit 5-8 minutes and can put in blender with berries, water, almond milk, nuts.  Need to keep oil in refrigerator from Barlean’s, 800-445-3529.
    7. General Diet: For “slow oxidizers” with dominant parasympathetic system, too alkaline so don’t want strict vegetarian diet. For “fast oxidizers” with dominant sympathetic systems, avoid animal protein and maximize vegetables. People need to try different diets to see which makes them feel best.  All agree to avoid sugar, processed foods, dairy and gluten. Best diet book is The China Study by T. Colin Campbell and emphasizes that Americans eat too much animal protein. [Can do food sensitivity testing to avoid inflammatory foods.] Want to eat fruits, vegetables, sprouted breads, cereals from millet, quinoa, amaranth or buckwheat and nuts. [Can differentiate slow vs. fast oxidizer through HTMA.]

     

     

    The Truth About Cancer by Ty Bollinger notes

     

    Hoxsey Clinics now in Tijuana as Bio Medical Center

     

    P51 “The idea that our modern medical system is actually trying to cure disease and keep people healthy is nothing but smoke and mirrors.”

     

    Center for New Medicine in Irvine, CA, Dr. Badakhshan says that many of the patients she sees suffer from immune suppression caused by persistent viruses like HPV, HSV, EBV, Lyme, parasites and are common predicators of cancer. Parasites and other microbes suppress the immune system to help maintain survival.

     

    Tumors with cancer cells are like “bags of poison” (p122) that the body has sequestered in order to neutralize and annihilate.

     

    Testing:

    • DCIS has increased by 328% since mammo introduced.  Single mammogram has up to 1,000 times radiation of a chest x-ray.  Better is thermography.
    • AMAS: 95% sensitive at picking up any cancer with one test and 99% sensitive with two tests.  Level above 135 means immune system is not clearing cancer cells adequately. Can use test to track success of treatments, lifestyle changes and other interventions.
    • Oncoblot: 96% accurate at identifying a cancer’s origin.  In one study for 26 different cancers, it picked up the cancer 99.3% of over 800 cases with no false positives and less than 1% false negatives.  Limit of detection is about 2 million cancer cells as compared with several billion cells for something that would trigger an abnormal mammogram. $850.
    • Nagalese test: cancer cells and viruses use this enzyme to knock out GcMAF and the macrophages that take them out.
    • High resolution blood test (HRB): blood test from a few drops goes beyond cancer issues and looks at cellular imbalances and irregularities that are early signs of different chronic illnesses.   High-resolution blood test (HRB) detects free radical damage, immune dysfunction, heavy metal detoxification and others.

     

    Prevention:

    1. spiritual element: at a minimum, on a physiologic level, people are lower levels of adrenaline and cortisol that can impair the immune system.
    2. Purpose
    3. Physical exercise especially with sweating to clear toxins
    4. Rebounding to help lymphatic flow through a mini-trampoline.
    5. Toxin avoidance: 70% of toxins from food.  Want organic real food and avoidance of processed foods. Need filtered water.
    6. Avoid trans fats like those in junk food, snacks, muffins, etc.
    7. Avoid processed sugar that “acts as fuel for cancer cells, fueling their anaerobic lust to ferment” (p147)
    8. Avoid MSG.  Book says it’s worse than alcohol, nicotine and many pharmaceuticals.
    9. Need vitamins, minerals and enzymes.

     

    Treatment Options:

    • Essiac Tea via Resperin’s Original Caisse Formula Tea with burdock root, sheep sorrel, slippery elm bark and Turkish rhubarb root
    • Hoxsey Tonic (ingredients on p166)
    • Cannabis (Hemp). “THC is in fact a proven anticancer substance with tremendous potential to make chemotherapy and radiation obsolete.” THC causes cancer cells to commit suicide and interfere with by targeting and switching off certain pathways that allow cancers to grow. CBD has adaptogenic properties that help balance adrenals and modulate hormones particularly in response to stress. THCA is the preheated acid form of THC and can be taken in the hundreds of mg range with antioxidant, anti-inflammatory and neuroprotective benefits. Can juice 15 cannabis leaves and two buds daily mixed with fruits and vegetables for chronic inflammatory conditions. Phoenix Tears is a cannabis oil.
    • Detoxification – toxins lower pH of blood which can be a breeding ground for microbe. Toxins deplete energy. Domino effect starting with colon/leaky gut into blood that overwhelms the liver such that toxins passed along to the kidneys, then lymph nodes and finally to the bladder when the body has reach its maximum, systemic toxicity. Dr Rashid Buttar addresses the “seven toxicities” including heavy metals, persistent organic pollutants (POPs), opportunistic microbes (bacteria, viruses, spirochetes, mycoplasma, yeast), energetics, emotional/psychological, food, spiritual.
    • Important to detoxify:
    1. Colon Cleanse: consider Optimoxx and/or regular colonic plus on daily basis good soil-based probiotic, avoid gluten, manage stress, avoid antibiotics, avoid steroids, avoid NSAIDs and eat lots of cabbage, broccoli, cauliflower, aloe vera juice.
    2. Parasite Cleanse: parasites feed on sugar. Need to rid body of parasites and their eggs so you need black walnut hulls, wormwood and cloves. First two kill more than 100 known parasites; cloves kill eggs.
    3. Kidney Cleanse: large amounts of watermelon, celery seed tea and can also be more aggressive with another product through epigenetic labs.
    4. Liver/Gallbladder Cleanse:
    • step 1 – drink one quart of organic, unprocessed apple juice every days for 3 days;
    • step 2 – on evening of 3rd day, drink 8 oz. of organic, cold-pressed, EVOO with juice of one lemon quickly;
    • step 3 –lie on right side in fetal position for 30 minutes, may vomit and then next morning may see gallstones in stool.  Other options including coffee enemas or epigenetic Labs option.

       e. Blood Cleanse (p183): hoxsey tea, essiac tea

     

    • Gerson
    • Others: Ozone therapy, Rife Machine, Hyperthermia, Hydrogen Peroxide, IV vitamin C, UV Blood Irradiation, Virotherapeutics (viruses) especially RIGVIR, Essential Oils (nearly all have anticancer properties) and some of the most potent for cancer include frankincense, oil of oregano, lavender, sandalwood, lemongrass, wintergreen, fir needle, lemon, lime
    • Enzyme and Metabolic/Mitochondrial Therapy

    a. autophagy: an important process (p259) and “is the catabolic process by which cells constantly degrade their own unneeded cell components in order to promote new cell growth and maintain homeostasis.” “Autophagy lies at the heart of cancer prevention it’s how our bodies attain and maintain optimal health.” “Cancer isn’t a genetic disease but rather a metabolic disease characterized by damaged cellular metabolism.”

     

    b. Proteolytic enzyme therapy is an effective treatment against pancreatic and other forms of cancer. Dr. Gonzalez clinic has three components: diet, aggressive supplementation with nutrients and pancreas products (containing naturally occurring enzymes) and detoxification. For proteolytic enzymes, a good option will contain protease, pancreatin, nattokinase, seaprose, papain, bromelain, amylase, lipase (p273). Proteolytic enzymes have many benefits including:

    1. Enable cellular mitochondria can synthesize proteins, induce cell apoptosis, eliminate waste and other necessary functions.
    2. Help control systemic inflammation
    3. Repair and rebuild cardiovascular system
    4. Improve blood flow
    5. Optimize immune function
    • Issel Clinic three main components:

    1. Cancer-fighting vaccines to stimulate dendritic cells, innate and adaptive immunity

    2. Immune-enhancing protocols including systemic hyperthermia

    3. Immunobiologic core treatments

  • Cardiovascular Prevention and Management

    Cardiovascular Prevention and Management

     

    A. Key Elements

    1. Stress management

    2. Exercise

    3. Nutrition especially relative to increased vitamin and mineral deficiencies with age

    4. Gut health and intestinal permeability

    5. Inflammation

    6. Chelation

     

     

    B. Mainstream

     

    Work-up beyond a history and physical: fasting lipid profile, fasting glucose, A1c, CRP-hs and then, if patient is symptomatic, cardiac testing that can include treadmill stress test, stress test with nuclear imaging, echocardiogram, stress echocardiogram, cardiac catheterization, coronary calcium scan and others.

     

    Mainstream treatments: pharmaceuticals like statins, antihypertensives, exercise, low fat diets, low calorie diets.

     

     

    C. Resources

     

    1. The Calcium Lie II book or Youtube lecture by Robert Thompson, MD

    2. Youtube interviews with Rhonda Patrick, PhD on Infrared Sauna

    3. Dr. Dean Ornish’s Program for Reversing Heart Disease: The Only System Scientifically Proven to Reverse Heart Disease Without Drugs or Surgery by Dean Ornish, MD

    4. Forks Over Knives: The Cookbook by Del Sroufe and Isa Chandra Moskowitz

    5. Wheatbelly by William Davis, MD

     

     

    D. Testing Options

    1. Cardiac testing as above

    2. Labs: as above plus Alternative cholesterol analysis check for small, dense LDL vs. fluffy LDL

    3. Urine for organic acids (OAT)

    4. Methylation cycle analysis including MTHFR, CBS, COMT and NOS

     

     

    E. Options for Treatment/Management/Prevention:

    1. Innate Whole Food Vitamin C at 1,000-2,000mg daily

    2. BP control: Pharmaceuticals (but need to be cautious about secondary mineral deficiencies), relaxation, Restorative Formulations supplement with rauwolfia –HTN 180 Px Original or Extra Strength, Resperate device

    3. Stress management: meditation, yoga, biofeedback, self-hypnosis

    4. Metabolic dysfunction and Insulin resistance management: see section below

    5. Good hydration: One study showed that men over 50 who had less than 2 cups of water daily had the highest rates of heart attack and those who drank 6 cups of water or more daily had the lowest rates of heart attack.

    6. Regular, vigorous exercise (with appropriate mineral supplementation)

    7. NOS management as needed including l-arginine (through supplements like Perfusia), BH4, methyfolate, B12 (methyl, adenosyl or hydroxyl, not cyanocobalamin)

    8. Correcting mineral imbalances including:

    a. sea salt and avoidance of NaCl refined table salt

    b. trace ionic minerals with meals preferable as they are water soluble and more bioavailable to our bodies

    9. Antiinflammatory approaches including:

    a. curcuwin decrease inflammation and decrease risk stroke/CAD take 1-4/day,

    b. dietary changes with emphasis on organic vegetables and fruits with avoidance of gluten, wheat, sugar and dairy

    c. Omega-3 fatty acids: 2,000-3,000mg daily in forms like Omegaberry, Nordic Naturals

    10. Infrared sauna.

    11. IV EDTA chelation therapy.

     

     

    Notes:

     

    Hypertension

    * preferably a 2 year window of correcting/reversing many illnesses related to mineral imbalances.

    * the correct treatment of hypertension depends on knowing the intracellular content of minerals.

    * 90% of people need more sodium with low reserves.

    * adrenal suppression leads to sodium and potassium dumped in urine and calcium leaks into the cells too rapidly.

    * excess calcium goes into cells and arteries.

    * for most hypertension is combination of: excess calcium, low intracellular sodium and intracellular amino acid deficiencies

     

  • Chronic Arthritis and Autoimmune Conditions

    Chronic Arthritis and Autoimmune Conditions

     

    Of note, there are many different types of arthritis. Osteoarthritis (OA), often referred to as degenerative arthritis, is the most common form of chronic arthritis. We need to assess OA in context of age, weight, nutrition, gut health and other factors to see if it is appropriate.

     

    Other types include Rheumatoid Arthritis, gout (from the build-up of uric acid crystals in the joints), pseudogout (from the build-up of calcium pyrophosphate crystals in the joints), Lupus, Lyme disease and other tick-borne illnesses like Bartonella.

     

     

    A. Key Elements

    1. Inflammation: understanding the variety of factors that increase or decrease inflammation
    2. Food Sensitivities
    3. Gut/Microbiome/Intestinal Permeability/SIBO
    4. Lyme and Tick-Borne Illnesses
    5. Chronic Inflammatory Response Syndrome (CIRS)
    6. Toxin Exposure relative to innate detoxification, environment and lifestyle

     

     

    B. Mainstream

    • Work-up beyond a history and physical: Imaging modalities like x-ray, CT and MRI. Laboratory testing like rheumatoid factor (RF), antinuclear antigen (ANA), anti-double stranded DNA, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-CCP, others.
    • Mainstream treatments: Depends on diagnosis. NSAIDs like ibuprofen (Advil, Motrin), Naprosyn (Aleve), cortisone shots, physical therapy, occupational therapy, immune modulating and suppressing medications like Remicade.

     

     

    C.  Resources

     

     

    D. Testing Options (in addition to mainstream options)

    1. IgG food sensitivity testing through labs like Alletesse, FIT, Great Plains, Genova, Cyrex and others.
    2. SIBO testing through labs like Commonwealth Labs and Cyrex.
    3. Tick-borne infection testing with a variety of options (as below)
    4. Labs that would include a panel for CIRS (as below)

     

     

    E.  Options for Treatment/Management/Prevention

     

    Basic Protocol:

    1. History, physical, basic laboratory tests and imaging trying to sort out root causes from a functional perspective. This could include:
      1. preliminary laboratory testing for Lyme, Bartonella and other tick-borne causes including Lyme Western Blot, CD 57 panel, C3a, Galaxy Bartonella test based on individual factors.
      2. VIP, alpha-MSH, ADH, HLA DR DQB 1, C4a
    2. Avoidance of pro-inflammatory foods (especially sugar and gluten) and consumption of anti-inflammatory foods (as below) potentially based on IgG food sensitivity testing through Alletesse, FIT, Cyrex or other labs.
    3. Gastrointestinal support through fermented foods, prebiotics, probiotics, digestive enzymes, betaine HCl with pepsin and other options based on factors like presence or absence of SIBO.
    4. Supplementation with Omega 3s (at least 2,000 mg daily), vitamin D (to get 25-OH level to at least 40), SAMe 400mg daily, Turmeric/curmin (with options that include Curcumasorb from Pure Encapsulations or Curcuwin) and others.
    5. Physical therapy and exercise
    6. Stress management
    7. Use supportive treatments as needed depending on level of pain and disability including NSAIDs like ibuprofen and naproxen; diclofenac (Voltaren) gel; lidocaine gel, cream or patch.
    8. Assess status and broaden work-up and treatment regimen as needed.
    9. Consider Low Dose Naltrexone (LDN).
    10. For autoimmune conditions, read/watch The Autoimmune Fix by Tom O’Bryan and The Betrayal Series.

     

     

    F. Notes:

     

    Factors that increases joint inflammation:

    1. Foods: sugar, gluten, wheat, dairy and other foods as identified by food sensitivity testing
    2. Stress: through increases in cortisol, increased intestinal permeability and other factors
    3. Toxins
    4. Infectious agents like Lyme, Bartonella, EBV virus, intestinal parasites and many others.

     

    Factors that reduce joint (and systemic) inflammation:

    1. Vigorous Exercise
    2. Adequate Sleep
    3. Stress reduction techniques like yoga, meditation, biofeedback
    4. Omega-3 fatty acids (fish oil)
    5. Turmeric/Curcumin
    6. Diets like a Paleo diet with organic fruits/vegetables, nuts, seeds and high quality protein (fish, shellfish, beef, lamb, liver)

     

    Betrayal Series Notes

    Episode 1

    • All autoimmune patients have leaky gut and need GI evaluation, program and gluten/wheat free.  Kalish won't treat people with gut testing.
    • Zonulin has protective benefit for Cholera but opens tight junctions as a response to modern wheat.
    • Transit time: eat 2 ears of corn to see how long it takes for it to come out.  first see to last see = how long it takes.  should be less than 24 hours.

     

    Episode 2

    • Signs of leaky gut: frequent stools, undigested food, fatty stools, quick transit time
    • Can do food-mood-poop journaling.
    • Fat-fiber-protein in each meal to stabilize blood sugars
    • Need acid with pH 1-5-1.9 especially to break down protein and get the essential amino acids we need for everything.  within 1-2 weeks of PPI, autoantibodies develop against food (increased reactivity 10-fold)  PPI plus leaky gut is serious problem.  Betaine HCl with pepsin.  PPI can change stomach pH to a 5!
    • B12 signs: headaches, poor detox, fatigue, neuropathy, muscle twitching, muscle pain
    • Inflammation is a "metabolically demanding process" that drains the body of nutrients, methyl donors, glutathione.
    • Autoimmune puzzle: intestinal permeability (100%) ---> food sensitivities, inflammation plus LPS/endotoxin, hydrogen sulfide, d-lactic acid), dysbiosis (some specific microbes can initiate the process), malabsorption (with nutrient deficiencies), SIBO, vitamin D (with Jigsaw SRT), gluten, parasites [kalish won't treat someone unless they do gut testing up front].
    • Parasites: mostly people don't have symptoms
    • Vitamin d is "most important immune modulating substance." Often getting level to 40-60+ can reduce pain and inflammation. 6% of BSA for 15 minutes middle of the day, get equivalent of 600 IU.

     

    Episode 3

    • Most important thing anyone can do is to "fix the microbiome"
    • 1gm of stool has more bacteria than stars in the universe.
    • Commensal bacteria keep pathogens in check.  LPS is part of wall structure of bacteria.
    • Don't see autoimmune disease in 3rd world.  spore bacteria have capability of flagging good bacteria so immune system sees them as pathogenic!  our immune cells are trained by microbes.
    • C-section baby gets different populations of bacteria from surgeon, operating room more than mother in a sterile surgical environment -- more risk of atopy.  use sponge in mother's birth canal and then wipe the baby's face.  99% of the DNA in our bodies is microbial.
    • RF is an IgM reactive antbody and "we're not sure" what that is against.
    • Dysbiosis: avoid wrong foods (processed, packaged, sugar) and eat best foods especially raw fruits and vegetables foods with insoluble fiber and fermented foods (ACV with mother, kimchi, kamboucha, kefir, natural organic unsweetened yogurt, miso, tempeh) plus prebiotic/probiotic like Dr. Ohhira, Prescript Assist; fiber can feed good or bad bacteria.  if vegetables lead to GI sx, probably a SIBO situation and methane/hydrogen are being produced.  can't do it without food/diet as primary approach.  probiotics alone won't do it.  want great diversity of gut flora so rotate probiotics.  (Human Microbiome Project)
    • Our ancestors consumed 1,000 different foods over a year.  ethnic foods will add variety and diversity.
    • Apple: 2 per day in mice with colitis reduced inflammation equivalent to 10-15 mg prednisone. Cook apple with skin until it starts to break down and that maximizes benefit -- add cinnamon, raisins. Inflammatory bowel conditions will improve but may need to work up gradually starting 3-4 tsp.
    • Restore gut lining: zinc, fish oil, glutamine, Restore, spore-based probiotics, vegetables with AHL, avoid alcohol.
    • Rhematoid Arthritis: looking for klebsiella, citrobacter, proteus overgrowth through stool analysis.
    • With yeast overgrowth, people often crave sugar, refined grains (white flour, white rice) that feeds the yeast.
    • "Eat at a table not a desk."
    • Glyphosate (Roundup): hard on good bacteria in us and in the soil. Damages pathway that we don't have but bacteria do and don't produce folate among other things.
    • Some vegetables like cabbage,  have aryl hydrocarbon ligands (AHL); if bitter, that means the plant still has good immune function itself

     

     Episode 4

    • Off gluten; hashimoto's antibodies decrease; core of autoimmune disease is disruption of the gut barrier.  food molecules "find a home" in certain parts of the body.  "the most inflammatory thing we do all day is eat."
    • Gluten and wheat germ agglutinin -- wheat may be more of the problem than gluten proteins.  we're not meant to eat grains that are basically cultivated, modified grasses.
    • Uses a "dedicated intake specialist" (Amada Huff??) to create a detailed timeline.
    • UC: use SCD diet? (from book Breaking the Viscous Cycle by Elaine Gottschall) and parasite evaluation.
    • Sugar suppresses stomach acid production.
    • Curcumin may be "the most profound inflammatory modulator on Earth" -- paper showed that it affects 84 molecular targets in cancer cells.
    • TNF agents hit one of the 84 and are like "sledge hammers" that then predisposes the person to cancer and infectious diseases.

     

    Episode 5

    • 1 billion pounds of pesticides used in American agriculture every year.
    • Every newborn has, on average, 280 toxic chemicals in their bloodstream at birth.  108 are found in all Americans.
    • Tuna, swordfish but also sea bass is high in mercury.
    • Supermarket chicken INCLUDING ORGANIC is bathed in chlorine.
    • To avoid flame retardant chemicals, everyone should be wearing organic cotton.
    • Walking on asphalt puts heavy metals on to the shoes, so one more reason to take off shoes when you enter a house so you don't track heavy metal around especially if you have an infant that will be crawling around on the floor.
    • Bisphenol A or BPA is the main chemical in plastic products including bottles, utensils and it is sprayed inside tin cans and on paper towels. Can see levels in the urine. BPA is an endocrine disruptor. BPA-free can use BSA which is more toxic. "Plastic is plastic." Use glass or metal thermos as much as possible. "The biggest insult, though, is when people drink coffee through a coffee lid...The heat releases BPA into the liquid."
    • Avoid cheap, nonstick saucepans because Teflon is another endocrine disruptor. Scanpan is a good alternative or La Creuset.
    • EMF exposure is a hormone disruptor for the adrenal gland. The younger you are, the more EMG penetrates the body from cell phones, etc. "There's some good data that shows the depth of penetration of the brain for little kids versus adults is much, much more dramatic." Better to talk with a headset.
    • Easy way to assess electromagnetic radiation exposure: turn on smartphone and try to connect to wireless and see how many wireless networks are within range. Can use a Graham-Stetzer meter. Can buy a filter for the home for "dirty electricity."
    • Cosmetics are major source of heavy metals and toxins: Burt's Beer lip shimmer has lead. Chanel lipstick has lead. "It's not as simple as you just do something like chelation therapy."
    • Dr. Walter Crinnion one of the world's toxin experts:
      • Car exhaust has greater association with cardiovascular risk than cholesterol.
      • "The greatest risk a woman for giving birth to an autistic child is how close she is a a busy roadyway. [based on 8 studies so far]"
      • Air toxicity can cause Alzheimer-like plaques even in children.
      • Toxins imbalance the immune system so that a person can't fight off virus or bacteria well through low TH-1, high TH-2, allergies.
      • Obesity clearly linked to phthalates and plastics. They damage the mitochondria, the immune system and affect metabolism. "The higher the amount in the urine, the bigger the belt size in males, females and children."
      • Autoimmune disease for 911 worker and others in construction sites can be related to silica exposure plus metals like aluminum.
    • Dr. Crinnion: "I think the number one thing people should do to be health, even before organic food, is get a high quality air purifier in their home, one that forces the air through a series of HEPA filters and charcoal filters." He has the Walters Holy Trinity. "Get the furnace vents sucked out, get the dust sucked out of them, because these environmental toxicants aren't free floating in the air, they're on the dust. Then, buy the high-quality, pleated, electrostatic air filters. They'll cost you 20 bucks a pop." Overall, the investment is "about a thousand bucks and...the opportunity is there to knock out the allergies, to prevent a woman having an autistic child, to reduce your risk of heart attack."

     

    You can ask hotels for HEPA air filters for the room!

     

    Episode 5 Summary:

    • Your toxic load equals the chemicals you are exposed to and cannot eliminate.
    • Here are some things that were mentioned in this episode and in the interview transcripts that help you reduce your exposure to chemicals:
      • Use stainless steel or glass water bottles and food storage containers. This will reduce your exposure to phathalates and BPA. These are two plasticizing agents that wreak havoc on your immune system.
      • Choose skin care and other personal care products that are free of fragrances, colors, parabens, silicones, triclosan, and other harmful compounds. You can find a great list of chemicals to avoid and products to buy at http://www.ewg.org/skindeep/.
      • Take your shoes off before entering your house. This reduces chemicals that get on your flooring.
      • Purchase organic cotton and hemp clothing and bedding materials to reduce your exposure to harmful dyes and flame retardants.

     

    Betrayal • Episode 5 - Environmental Toxins: The Hidden Drivers of Disease

    • Purchase organic foods whenever possible. If they are not available, refer to the EWG.org clean 15 and dirty dozen lists.
    • Clean your air with an air purifier that gets rid of VOCs and new pleated electrostatic air filters for your furnace. Remember to have your ducts cleaned too as toxins will accumulate in the ducts.
    • Here are a few ways you can increase your clearance of toxins:
    1. Make sure you have daily bowel movements. IF your bowel movements are backed up, you will absorb more toxins in your intestines.
    2. Get plenty of sleep and reduce stress. Your body detoxifies when you rest.
    3. Increase your consumption of broccoli, cauliflower, cabbage, kale, Brussels sprouts, arugula, radishes and other cruciferous vegetables. They will ramp up your ability to detoxify chemicals.
    4. Drink plenty of [filtered] water to increase your urine output and your ability to sweat. Many toxins travel out of the body via sweat and urine.
    5. Exercise, take hot baths and do saunas to increase sweating.

     

    Episode 6

    • Insulin resistance (and type 2 diabetes) is consistent with inflammation and “brain cells can’t take blood sugar…and you can’t feed your brain.  It doesn’t get energy. It’s energy starved and it doesn’t function. That’s the first stp to slow death and brain shrinkage and Alzheimer’s, memory loss.”
    • Multiple Sclerosis: wheat sensitivity with an autoimmune reactivity and positive antibodies is a major player.  The number one target for autoimmunity in MS is myelin basic protein. Can get “gluten ataxia” where the target is within the cerebellum and so people have balance problems.
    • Mental Health: with anxiety and depression and cognitive dysfunction you often see high levels of transglutaminase 6. Avoid wheat for 2-4 weeks and there can be dramatic changes.
    • People can “lose their blood-brain barrier and have immune chemical reactivity and then these chemicals start to interact with glial cells that can turn on the autoimmune reaction against the brain.” Other things that disrupt the blood brain barrier besides wheat, traumatic brain injury, alcohol, drugs, systemic inflammation, heavy metals like mercury. Can be cumulative/combination of factors: head injury plus alcohol plus chemicals plus lack of sleep.
    • Need to check for thyroid antibodies, leaky gut and food sensitivities for those with psychiatric issues.
    • For those anxious, not sleeping well, wired and depressed it’s often a “serotonin deficiency” so Hyla Cass will use 5-HTP with B-vitamin cofactors especially B6 and magnesium.
    • Parkinson’s: “There’s a very strong toxicity component and there’s either heavy metals or chemical or some kind of neurotoxin that’s damaging the dopamine centers of the brain. It’s never as simple as detoxifying the person until they get better but that’s a really essential component for most of these neurological conditions.”
    • Gut/microbiome issues are important and constipation usually precedes Parkinsonian problem up to many years beforehand. Study correlated the amount of antibiotics people had within 10 years of onset of the PD with the rate of progression. “It’s back to toxicity in the gut and detoxing and breaking things down.”
    • If you get a person within the first year of diagnosis, functional approaches will have the most benefit. Almost all have Dysbiosis. Need to clear the liver pathways and use amino acid programs to help balance the brain.
    • Austism: Liz Lipski, PhD, uses a “comprehensive elimination diet” consisting of fruits, vegetables, non-gluten grains, fish, chicken, butter, ghee and this can calm down behavioral problems, incontinence issues, etc.
    • ADD: some kids have “reward deficiency syndrome” with low dopamine because they’re either producing less dopamine or the receptors aren’t as active [or the receptors are blocked]. Usually father is same and can have issues with alcoholism, ADD, depression, anxiety, bipolar, gambling.
    • Dr. Datis Kharrazian treatment before testing: 1. Paleo type diet with no junk, no sugar, no white flour; 2. Omegas like Super EPA 2 in morning; 3. Two Focus Product with tyrosine, phenylalanine and cofactors to help increase dopamine production.
    • Function Neurology: Tom O’Bryan uses term “function neurology” to improve brain function through exercise, rehabilitation like eye movements, balance exercises, nutrition (to decrease brain inflammation), supplements to increase neurotransmitter activity.
    • In terms of the brain, you do exercises for whatever areas need improvement: balance, numbers, handwriting, etc.
    • Study with 118 randomly selected patients and 63% had IgG antibodies against gluten family proteins as non-celiac gluten sensitivity with autoimmune type attacks on tissue, most commonly the brain/nervous system, adrenal #2, heart #3. Gluten is “foreign to our body.” 76% of people had antibodies against wheat germ agglutinins and antibodies against their own tissue and this is a different mechanism from gluten.
    • Can see “neuromyelitis optica” with inflammation of optical pathways in brain. Receptor called aquaporin that allows food to cross. Soy and tomato and spinach have aquaporin proteins. “For aquaporin associated autoimmunity, different foods have different autoimmune potential based on their amino acid sequence to different tissue target situes where the immune system’s attacking. They found 25 new proteins that can cross-react with tissue in cerebellum. Yeast and rice were off the charts (and many on gluten-free diet eat those foods).
    • Mold: Raises TGF beta (1) that drives TH 17 that drives auto immunity.
    • Aluminum: Vaccines have aluminum and that can be neurotoxic and impair the immune system. Baby formula often has aluminum possibly from China. Baking soda and based good mixes can be a source. Over 900 studies show aluminum is neurotoxic.

     

    Episode 7

    • For autoimmune conditions, start with the gut. Hippocrates said “All disease start in the gut.”
    • Often start with no gluten, no dairy and probiotics.
    • Consider GAPs protocol from Natasha McBride.
    • Episode 7 is stories of people with autoimmune conditions like MS who fully recovered.

     

    Episode 8

    • Hashimoto’s: often need iron (and vitamin C) in diet or supplements. No gluten, dairy and soy and can take many months to see the antibody levels drop.
    • Psoriasis: diet changes especially Paleo with good intake of health fats, stress management. Eggs can be a trigger.
    • Reflux: Can resolve quickly on gluten-free, dairy-free diet.
    • Adult acne: Can clear quickly with diet that avoids gluten and dairy and sugar. Need healthy fats and to make sure there is good aborption. Eggs can also be a trigger.

     

    Episode 9

    Study: In first year after a diagnosis of celiac, the person has 280% increased risk of dying from cancer, 85% increased risk of dying of cardiovascular disease with 300% increased risk of dying from suicide within 5 years.  Some degree of social isolation and social phobia for kids because they don’t want to come across as weird or different.  [Some of these numbers reflect the typical delay of diagnosis with celiac.]

     

  • Diabetes Prevention and Reversal

    Diabetes (and Metabolic Syndrome) Prevention and Reversal

     

    A. Key Elements

    1. Diet and nutrition: avoiding processed sugar and wheat-based carbohydrates.
    2. Chromium, vanadium, magnesium and mineral deficiencies: chromium deficiency leads to insulin resistance because chromium is a co-factor for the enzymes that help insulin to function.
    3. Gut Health/Microbiome
    4. Toxins and Detoxification
    5. Leptin Resistance
    6. Chronic Stress

     

    B. Mainstream

    • Work-up beyond a history and physical: Minimal.
    • Treatments: pharmaceuticals like Glucophage (Metformin), sulfonylureas like glipizide, Avandia, Actos, Januvia, Invokana and insulin

     

    C. Resources

     

    D. Testing Options

    1. fasting glucose, A1C, cortisol, RBC magnesium and glucose/insulin ratio: lower is worse especially below 7 (trig over 100 and fasting insulin levels over 10 often signs of insulin resistance also)
    2. Hair Tissue Mineral Analysis from Great Plains Labs, Trace Elements, other
    3. Comprehensive Stool Analysis from Great Plains Labs, Genova, other
    4. Urine for Organice Acids Test (OAT)
    5. GPL-Tox Screen from Great Plains Labs

     

    E. Options for Treatment/Management/Prevention

    1. Avoidance of processed sugar and wheat-based carbs
    2. Use of mineral supplementation especially Chromemate 600mcg two or three times a day with meals.
    3. Good probiotic and/or probiotic enemas.
    4. Individualized detoxification program based on testing.
    5. Infrared sauna help insulin resistance.
    6. Regular, vigorous exercise
    7. For leptin resistance: dramatic dietary changes, L-acetyl-carnitine, Irvingia Gabonensis and consider Byetta once or twice daily.
    8. Pharmaceuticals and insulin as above

     

    F. References and Notes

    Pizzorno Toxin and Detoxifiation notes from AARM Conference 2016:

    • Diabetes Mellitus risk doesn't have as much to do with sugar as was once thought.
    • Toxins explains almost all of the 10-fold increase in risk: 70% from food, 10% water, 10% house/yard, 5% health and beauty aids, 5% air.
    • Toxins block insulin receptors sites, damage pancreas beta cells and lead to epigenetic dysmodulation.
    • Round-up weed killer is 50% glyphosate and 50% petroleum distillates
    • Glutathione detoxifies most POPs (persistent organic pollutants) and can monitor through GGT reduction.
    • GPL-Tox screen test covers 150 different chemicals and blood tests are generally better since most fat soluble (vs. water soluble into the urine)
    • Of the cytochrome P450 liver enzymes responsible for detoxification, some are more important: CYP 2D6 metabolizes 25% of all drugs; CYP 2C19 is second most important. If a person is prone to adverse drug reactions, they typically don't clear toxins well either.
    • Can use stabilized rice bran as good source of fiber to help bind those toxins dumped into the gut.
    • For provocation test, Pizzano uses 500mg DMSA and 300mg DMPS and then first morning urine and six hour urine for lead and mercury.

     

    Leptin:

    People who are leptin resistance are experiencing great success on a “high good fat” diet which can be used as an effective leptin resistance treatment program. These good fats are monsaturated fats like olive oil, canola oil, avocados, nuts and seeds, olives and dark chocolate. Also, one who is leptin resistant should know that eating a diet that is high in carbohydrates and saturated fats is the worst thing to do if you are leptin resistant. Foods like breads, grains, cereals, starchy vegetables, pasta etc. should be avoided at all costs if you are leptin resistant. All sugars and junk foods should be avoided.  Can use Byetta and/or Irvingia Gabonensis herbal product.

     

    In rodent models, acetyl-l-carnitne and ginseng improved leptin resistance.

     

  • Fibromyalgia and Chronic Fatigue Syndrome

    A. Key Elements: People with these diagnoses can have any of these alone or in combination and potentially other contributing factors as well.

     

    1. Chronic Inflammatory Response Syndrome (CIRS) from mold/biotoxin

    2. Lyme, Co-infections and Tick-Borne Illness

    3. Food Sensitivities

    4. Mineral Deficiencies and Imbalances

    5. Small Intestinal Bacterial Overgrowth (SIBO) with LPS and hydrogen sulfide toxins into the system

    6. Thyroid Dysfunction

    7. Hormonal Imbalances

    8. Chronic Active Viral Infections especially HSV-6, EBV, CMV and Parvovirus

    9. Phosphate/Calcium Deposition into Muscle Tissue per St. Amand

    10. Mitochondrial Dysfunction:

    11. Toxic Load with Poor Innate Detoxification

    12. Systemic Candida/Fungal Overgrowth

    13. Methylation Cycle Anomalies

    14. Chronic Parasite Infections

     

     

    B. Mainstream work-up beyond a history and physical: Minimal for fibromyalgia. Standard laboratory testing for chronic fatigue would include TSH, CBC, iron profile, B12 and complete metabolic profile (CMP)

     

    Mainstream treatments: Pharmaceuticals for fibromyalgia including gabapentin, Lyrica, Cymbalta and Savella. No treatments for chronic idiopathic fatigue.

     

     

    C. Resources

     

    • Surviving Mold by Ritchie Shoemaker, MD
    • Why Can’t I Get Better?  by Richard Horowitz, MD
    • The website gotmag.org and the Magnesium Advocacy Group (MAG)
    • Thyroid Healthy by Suzy Cohen, RPh
    • Overcoming Thyroid Disorders by David Brownstein, MD
    • The Hormone Cure by Sara Gottfried, MD
    • What Your Doctor May Not Be Telling You About Fibromyalgia by R. Paul St. Amand MD
    • The New Fibromyalgia Remedy by Daniel Dantini, MD
    • Blog Posts at drlenhardt.com

     

    D. Testing Protocol:

     

    Step 1: History and physical especially to assess likelihood of St. Amand phosphate muscle condition, SIBO and others.  Labs including CBC, CMP, B12, thyroid panel, VIP, alpha-MSH, ADH, Lyme western blot and/or CD 57 panel and/or Lyme Nanotrap; RBC magnesium plus elimination diet (bottom up).

     

    Step 2: Manage issues from Step 1 and then consider other testing, changes including

        a. EBV quantitative antibody panel 1 from ARUP (#0050600), HHV-6 titers, CMV titers

        b. other Lyme testing (like Urine for PCR from Igenex) or co-infection testing especially for Babesia, Bartonella, Mycoplasma and others.

        c.  FIT testing or Cyrex array panel(s) for food sensitivities

        d. hormonal questionnaire from The Hormone Cure and hormone labs

        e. Hair tissue mineral analysis (HTMA).

     

    Step 3: Reassess on an ongoing basis which of the 14 underlying causes are active trying to determine primary vs. secondary and treat accordingly.

     

     

    E. Effective Options for Treatment/Management/Prevention:

    Depend on test results and other evaluations and needs to be individualized but some of the options corresponding to the 14 causes include:

     

    1. CIRS: Complex regimens with up to 12 or more steps that should be done in a recommended order for maximum benefit.  Patients with genetic haplotype vulnerability based on HLA DR DQB1 status should have ERMI done via the website mycometrics.com.  Start with laboratory testing that includes VIP, alpha-MSH, TGF Beta 1, ADH and others.

     

    2. Lyme and tick-borne illness: Complex regimens individualized based on various issues but includes:

    a. Antimicrobials: oral antibiotics, IV antibiotics, IM antibiotics like Bicillin and/or herbal protcols per Buhner, Cowden and others and/or oral silver as Mesosilver, Argentyn-23 and others.

    b. Immune support

    c. Microbiome support with prebiotics, probiotics, fermented foods, other

    d. Nutrient support through diet and supplements

     

    3. Food Sensitivites: Elimination diets or dietary adjustments based on testing from Cyrex, FIT, Alletesse or other labs.

     

    4. Minerals Deficiencies and Imbalances: Dietary changes and supplements based on tests like RBC magnesium, RBC folate, RBC zinc, MCV, hair tissues mineral analysis (HTMA) and/or urine for organic acids (OAT)

     

    5. SIBO: Treatments based on results of tests from labs like Commonwealth Labs, Genova, Great Plains and others.

     

    6. Thyroid Dysfunction: address adrenal issues first and then treat with some combination of levothyroxine, Armour/Nature-Throid/WP Thyroid, T3 liothyronine or extended release T3 from compounding pharmacy after thyroid profile that includes TSH, free T4, free T3, reverse T3, antithyroglobulin antibody level, antithyroid peroxidase and/or thyroid ultrasound.

     

    7. Hormones: Questionnaire from The Hormone Cure and then lifetstyle changes, herbs, supplements and bioidentical hormone therapy based on lab profile that includes estradiol, progesterone, DHEA-S, free testosterone, pregnenolone and others.

     

    8. Chronic Active Viruses

    a. antivirals: valacyclovir and/or L-lysine and/or cat’s claw

    b. anti-inflammatory diet: either avoidance of gluten/wheat/dairy/processed sugar or based on food sensitivity testing (see #3 above)

    c. immune support: zinc, whole food vitamin C and/or supplements like Daily Immune from Pure Encapsulations

     

    9. St. Amand: body mapping preferably and research then work up gradually on guaifenesin dose (Mucinex or company from California) from 300mg twice a day up until therapeutic dose is found plus avoidance of salicylates in all forms except food.

     

    10. Mitochondrial Dysfunction: Based on variety of tests especially the urine for OAT and others. Each step of mitochondrial electron transport chain requires specific nutrients to generate ATP: complex 1 needs B2, B3 and CoQ10; complex 2 requires B2, iron, DHA and CoQ10; complex 3 requires iron; complex 4 requires vitamin C and copper.  Can consider the Mitochondrial Support supplement from Pure Encapsulations.

     

    11. Toxic Load: Complex topic but testing can include blood, urine and/or hair analysis for heavy metals and GPL-Tox Screen from Great Plains Labs. Treatments vary according to individual factors but includes chelation strategies, glutathione (nasal, topical or suppository), N-acetyl cysteine (NAC) and many others.

     

    12. Systemic Fungal Overgrowth

    a. dietary changes: eliminate or minimize processed sugar, wheat, dairy and alcohol

    b. microbiome: prebiotics, probiotics, fermented foods and especially S. Boulardi (Florastor)

    c.  antifungals: prescription antifungals like fluconazole and nystatin for short courses vs. herbals options

     

    13. Methylation Cycle Anomalies: 23andme.com and then reports via other sites like geneticgenie.org, mthfrsupport.com, livewello.com or others and then complex management based on results.

     

    14. Parasites: Testing from different labs including Great Plains, Doctor’s Data, Genova and others and treatment based on results.

     

    Other Potential Treatments:

    1. Systemic enzymes with serrapeptase working up gradually on the dose and can take 3-6 months or longer for full benefit

    2. SHINE protocol

    3. D-ribose

    4. Essential Oils

    5. Therapy, Self-Hypnosis, Relaxation, Infrared Sauna, Meditation, Exercise, Walking, Light Therapy

    6. Acupuncture and Traditional Chinese Medicine (TCM)

    7. Aryuveda

     

    F. References and Notes:

    RBC mag, plasma zinc, serum copper, serum ceruloplasmin (Cp) are metabolic markers.

     

    Copper (Cu) must be bound to ceruloplasmin to be usable.  Iron uptake enzyme activated by Vit C complex.

     

    1.   Zn/Cu ratio (optimal 1.2-1.3)

    2.  % unusable copper by Cu-(3*Cp))/Cu with optimal around 5%

    3.  % usable copper by 3*Cp/Cp with optimal 95%

    4.  serum transferrin optimal 3.0 g/L

    5.  serum Iron optimal 100 for women, 120 for men

    6.  TIBC optimal 285 women, 340 for men (and ideal sat = 25-30%)

    7.  Ferritin optimal at 20-50

    8.  Blood histamine optimal at 40-70 mg/dL

    9.  1,25OH D optimal 22-45

    10. 25OH D, storage form optimal at 15-30

    11. Ratio of 1,25/25 is 1.5-2.0

     

    Steps to Increase Ceruloplasmin

    1.   stop D (kills liver retinol needed for Cp production)

    2.  stop Calcium (blocks magnesium absorption)

    3.  stop iron (shuts down Cu metabolism)

    4.  stop ascorbic acid (disrupts Cu/Cp bond)

    5.  no HFCS, sugar or Omega 6s, fluoride, MVT, PNV, chlorine

    6.  need fat in the diet for proper copper absorption

    7.  START 1 tbsp Nordic Naturals for vitamin A

    8.  START Magnesium to lower ACTH and lower cortisol (5mg/lb body weight)

    9.  START wholefood vitamin C 500-800mg/day

    10. START B2, B5 and B7 through bee pollen ½ tsp daily, stabilized rice bran 1-2 tsp daily, beef/liver

    11. CONSIDER silica from diatomaceious earth, boron 1-3mg/day, taurine, ancestral diet, iodine

     

    Steps to Reduce Iron Burden: standard process wheat germ oil, ACV, fermented foods, donate blood

     

    Uses Anderson’s Mineral Drops without potassium or Aussie Minerals with potassium

     

    Options for restoring or optimizing Adrenal Function: ashwaganda, licorice root tea [if low cortisol], Innate Whole Vit C, adrenal cocktail (4 oz. OJ + ¼ tsp sea salt + ¼ tsp of cream of tartar) at 10am and 2pm

     

    Steps to Support/Cleanse Liver: milk thistle, cod liver oil from nordic naturals 1 tbsp/day without D

     

     

    HTMA Notes

    HTMA support if slow oxidizer (Standard Process Paraplex), elevated calcium (SP Cataplex F 3 perls/day)

     

    Ideal amounts: Ca 42, Mg 6, Na 24, K 10, Cu 2.5, Zn 20, P 16, Fe 2.2, Hg 0.02, Mo 0.0

     

    Key ratios:

    1.  most important is Na/K with ideal 2.40.  MR says this is “overall vitality”

    2. Second most important is Ca/Mg.  Says this is relative to blood sugar.  Ideal is 7.0.  If > 13, may be from overeating carbs, emotional conflict, defensiveness.  If < 3.3 can be from magnesium loss.

    3. Energy loss ratio is Ca/K and is thyroid ratio.  > 50 is extreme hypothyroidism with decreased thyroid effect at cellular level.  Ideal is 4.20.  < 1.0 is extreme hyperthyroidism.  If Low K < 4, body is exhausted.

    4. Ca/P: reflects autonomic nervous system and protein usage.  If high > 2.7 = parasympathetic.  > 8 = impaired immune response.  Ideal = 2.6.  If low < 1.5 = sympathetic.

    5.  Na/Mg = adrenal ratio.  Ideal 4.00.  High can reflect excessive adrenal effect at the cellular level, alarm, acute stress and/or toxins.  High high is > 20.  Low < 1.0 reflects extremem adrenal fatigue/suppression.

    6.  Zn/Cu

     

    Vazquez/SIBO notes

    Toxic load: SIBO causes increased levels of LPS/endotoxin (increases brain sensitivity via direct activation of NMDA receptors; increased perception of pain; impaired mitochondrial function and cytokine release), hydrogen sulfide and D-lactic acid (a neurotoxin and metabolic poison)

     

    SIBO leads to malabsorption and nutrient deficiencies including vitamin D and magnesium that can worse chronic pain.

     

    SIBO can lead to low L-tryptophan levels because of increased activity of bacterial tryptophanase.  FM patients produce 31% less melatonin affecting sleep and pain perception.  Lower 5-HTP leads to lower serotonin which can lead to more pain, depression, anxiety and food/cho cravings.  FM patients have low tryptophan proportional to level of pain 50-300mg/day.

     

    SIBO treatments: probiotics, vegetarian/paleo diet, vitamin A, zinc, L-glutamine plus antibiotics like rifaximin, cipro, augmenting, flagyl and/or berberine, artemisia, peppermint oil and oil of oregano and/or amino acid supplements, CoQ10 100mg three times a day, gingko 200mg daily?

     

    Most common food sensitivities: wheat 78%, orange 65%, eggs 45%, coffee 40%, chocolate and milk 37%, beef 35%

     

  • Gastrointestinal Health (including Irritable Bowel Syndrome, Acid Reflux, and SIBO)

    Gastrointestinal Issues including
    Irritable Bowel Syndrome, Acid Reflux, Dyspepsia and others

     

    A. Key Elements:

    1. Dysbiosis (flora imbalance)
    2. Intestinal permeability and “leaky gut” issues
    3. Small intestinal bacterial overgrowth (SIBO)
    4. Nutrient and mineral deficiencies
    5. Delayed food sensitivities
    6. Stress management
    7. Chronic Parasites

     

    B. Mainstream:

    • Work-up beyond a history and physical: many options include CBC, LFTs, H. pylori (blood, stool, CLO test, other), ultrasound, CT scans, MRI scans
    • Treatments: pharmaceuticals like laxatives, stool softeners, antispasmodics and acid blockers like Prilosec and Zantac

     

    C. Resources:

     

    D.  Testing Options:

    1. Comprehensive stool analysis with parasitology from Great Plains Labs, Doctor’s Data Lab, Genova or other including Parawellness.
    2. IgG (or IgA) food sensitivity testing from Alltesse, Great Plains Labs, KRBO FIT test, Cyrex panels or other labs.
    3. Cyrex Array 2 measure lipopolysaccharide (LPS) Ab levels.
    4. Urine for OAT

     

    E. Options for Treatment/Management/Prevention:

    1. Dietary changes based on top down or bottom up elimination diet (gluten/wheat, dairy, soy, corn, eggs).
    2. Apple Cider Vinegar with mother 1 tsp to 1 tbsp once or twice a day, e.g. from Bragg.
    3. Probiotics like Prescript Assist, Megafood from Megaflora, Dr. Ohhira, Life 9 from Young Living and others especially soil-based versions.
    4. Digestive Enzymes like Digest Gold.
    5. Betaine HCl with Pepsin (from Pure Encapsulations or other companies) for those with signs of low stomach acid including bloating, indigestion, bowel changes, undigested food in stools, don't take with NSAIDs. Only take with meals where you eat protein with dose up to 6 of the 650mg tablets, but can work up until you get warm feeling in stomach and dose can vary depending on meal volume, protein content, etc.
    6. DGL licorice: treats heartburn by absorbing acid without interfering with protein digestion plus need to replenish intracellular sodium levels. Can use rhizonate (licorice extract) chew one every 5 minutes until symptoms relieved.

     

    F. References and Notes:

    1. Microbiome and Gut Health:
      1. There are five core probiotic species: lactobacillus plantarum, lactobacillus acidophilus, lactobacillus brevis, bifidobacter lactis, and bifidobacter longum.
      2. Things that negatively impact microbiome: sugar, gluten, chemicals, chlorine, antibiotics, steroids, and stress.
    • Can shift flora balance with:
      1. Oral probiotics with or without prebiotics.
      2. Fermented foods like kamboucha, kimchi, sauerkraut, tempeh, miso and others.
      3. Probiotic Enemas (p 211 from the book Brainmaker).  Enema bag, 3-6 probiotic capsules, filtered chlorine free water, in morning, after BM,  fill large cup with 12 oz. lukewarm water. Dump in probiotics, stir. Fill enema bag. Lie down on side in tub.  Hold bag higher than nozzle, release clamp.  Try to hold 30 minutes up to 3x weekly for 4-6 weeks but work up gradually starting with 5 minutes once or twice a week.
    • Western microbiome lacks diversity with more firmicutes:bacteriodetes
    • Good gut bacteria can produce GABA, glutamate, BDNF and others. BDNF involved in neurogenesis and protects existing neurons.
    • Gliadin causes increased gut permeability and more permeable blood-brain barrier. Lipopolysaccharide (LPS) is an endotoxin from Gram negative bacteria and induces a violent inflammatory response.  Normally LPS is blocked by tight junctions.  Causes learning deficits, beta amyloid build-up. Alzheimer’s patients have 3x the LPS in blood. 2x for autism. LPS levels reduced by red wine.
    • Elevated cortisol changes the mix of bacteria, increases permeability of gut lining (esp TNF-alpha), increased cytokines but can be reversed with probiotic Bifobacterium infantis.
    • When tryptophan is degraded by certain enzymes, it is unavailable for serotonin production.  Kynurenine is a byproduct of tryptophan breakdown so higher levels correspond to low tryptophan levels.  Seen in those with depression, anxiety, Alzheimer’s and tic disorders.
    • Half of ADHD kids have hypersensitivity to dairy, wheat, processed foods, etc. GABA is deficient in the brains of ADHD kids. GABA comes from glutamine and the cofactors zinc and B6. Lactobacillus and bifidobacterium produce GABA in abundance. 2003 study: 20 kids with ADHD. ½ Ritalin and ½ l. acidophilus plus omegas – equal outcomes.
    • Gut bacteria make butyric acid (good and most important source fuel for cells lining the colon), acetic acid (good) and propionic acid (bad and produced by clostridia bacteria).
    • H.pylori helps control appetite by affecting levels of ghrelin.  If eradicate, people gain more weight.
    • Restore is a carbon rich, alkaline liquid, with lignite-derived trace organics and essential trace amino acids. With 70% of the immune system located in the gut, this optimal gut environment leads to great gut health. Restore is the first dietary supplement that delivers a balanced family of bacterial metabolites to promote a healthy firewall of tight junctions in the gut wall and blood brain barrier.

     

    2. Small Intestinal Bacterial Overgrowth (SIBO) Notes

    • Toxic load: SIBO causes increased levels of LPS/endotoxin (increases brain sensitivity via direct activation of NMDA receptors; increased perception of pain; impaired mitochondrial function and cytokine release), hydrogen sulfide and D-lactic acid (a neurotoxin and metabolic poison).
    • SIBO leads to malabsorption and nutrient deficiencies including vitamin D and magnesium that can worse chronic pain.
    • SIBO can lead to low L-tryptophan levels because of increased activity of bacterial tryptophanase.  FM patients produce 31% less melatonin affecting sleep and pain perception. Lower 5-HTP leads to lower serotonin which can lead to more pain, depression, anxiety and food/cho cravings. FM patients have low tryptophan proportional to level of pain 50-300mg/day.
    • SIBO treatments: probiotics, vegetarian/paleo diet, vitamin A, zinc, L-glutamine plus antibiotics like rifaximin, cipro, augmenting, flagyl and/or berberine, artemisia, peppermint oil and oil of oregano and/or amino acid supplements, CoQ10 100mg three times a day, gingko 200mg daily?

     

    3. Mitochondrial Dysfunction: Each step of mitochondrial electron transport chain requires specific nutrients to generate ATP: complex 1 needs B2, B3 and CoQ10; complex 2 requires B2, iron, DHA and CoQ10; complex 3 requires iron; complex 4 requires vitamin C and copper.

     

    4. Shawn Bean: “I see you have a heterozygous BCMO."

    BCMO gene expression represents the inability to convert from betacarotene to vitamin A. This conversion is significantly reduced in hypothyroidism without factoring the actual gene expression. Vitamin D taken at large dosages has been shown to decrease vitamin A and other fat soluble vitamins, Since you are heterozygous as well as having subclinical thyroid this expression goes from what appears heterozygous to a greater intensity similar to a homozygous. This is a prime example of how some things appear one way, but truly express another. You have also mention having GI related issue which vitamin A and zinc are crucial for proper repair of the GI mucosal barrier as well as G alpha protein in the gut as well in the brain. From your history, you appear to have symptoms of low thyroid, turn orange when you eat carrots or yams, exhibit a hard time seeing at night time as well as your mother side of the family having a history glaucoma, cateract, or macular degeneration. As one can see these factors clearly demonstrate how expressive this gene is as it related to your history and current symptoms.”

     

    5. Parasites: from the Parawellness Research website:

    • Most parasites enter the body through contaminated water or food and sometimes through poor sanitation habits. Parasites come in different forms. Protozoa are single celled organisms like the intestinal amoebas and malarial organisms. The multicellular organisms consist of roundworms, tapeworms and flukes. Yeast organisms when in excess can also be considered a parasite.
    • Gastrointestinal symptoms may consist of one or more of the following: flatulence, bloating, constipation, diarrhea, abdominal discomfort or cramping, maldigestion, malabsorption, irritable bowel, nausea, acid reflux, leaky gut syndrome, blood/mucus in the stool and odorous stool.
    • Nonspecific symptoms may include one or more of the following: fatigue, pain, skin disorders, allergies, insomnia, headaches, weight changes, nervous and sensory disorders, muscle weakness, immune deficiencies, night sweats and fever.
    • “Because these different symptoms could be associated with non-parasitic conditions some of which are very serious, it is important to rule in or out a parasite cause of the symptoms. To send a specimen off to a regular lab and get a negative test result does not rule out a parasite problem.
    • As it was explained to us, the gravitational pull of the moon on all bodies of water on earth effects the activity level of living organisms by expanding or contracting the water within them. The water content in parasites expands as the moon goes from barely visible to a full moon. As this happens the parasites become more irritable and will increase their consumption of nutrients. Giving parasite remedies during this time results in more effective elimination using lower doses. This has become standard procedure in our treatment plan and it works!
    • For the clients that we supervise we have put together parasite specific formulations of essential oils and a specialized non-colloidal form of silver.  The remedies are very specific to the type of parasite and the quantity we are dealing with. Treatment length is three months long in most instances and we time the taking of the remedies to the cycles of the moon during those months.

     

  • Memory Improvement, Dementia Prevention and Alzheimer’s reversal

    A. Key Elements:

    1. ruling out chronic inflammatory response syndrome (CIRS)

    2. ruling out  Lyme and tick-borne illness,

    3. assessing for mercury and heavy metal toxicity with ongoing exposure relative to poor innate detoxification

    4. functional medicine approaches

    5. fasting to promote autophagy

    6. quality and quantity of sleep

    7. stress management

    8. regular vigorous exercise

    9. nutrient deficiencies and dietary improvements with avoidance of acid blockers (especially PPIs) and statins if possible

    10. microbiome balancing

    11. relative immune deficiency and dysfunction

    12. iron overload

     

    B. Maintream work-up beyond history and physical: B12, TSH, CMP, RPR, MRI of the brain, mini-mental status exam (MMSE)

     

    Mainstream treatments: pharmaceutical like Aricept, Namenda and others but limited

     

    C. Resources:

    • Brainmaker by David Perlmutter, MD
    • Grain Brain by David Perlmutter, MD
    • Youtube lectures and interview with Dale Bredensen, MD
    • The Paleo Solution by Robb Wolf
    •  Interviews and podcasts at Chriskresser.com
    • Paleo cookbooks from Diana Rodgers at sustainabledish.com
    • CIRS information at survivingmold.com

     

    D. Testing Options:

    1.  Visual Contrast Sensitivity (VCS) screen at survivingmold.com plus labs like HLA DR and DQB1, VIP, alpha-MSH, VEGF, C4a, C3a and others to rule out CIRS

    2.  Lyme and co-infection testing to try and rule out tick-borne illness.  Urine for PCR through Igenex may be best single test, but can start with Lyme Western Blog and CD 57 panel.

    3.  Hair Tissue Mineral Analysis (HTMA) especially to check for mercury toxicity

    4.  Blood Tests: RBC zinc, RBC folate, homocysteine, B12, methylmalonic acid, TSH, free T3, reverse T3, CMP, CBC (especially to check MCV level), CRP-hs, APO E4

    5.  Rhinosinal culture looking for diversity and resistant bacteria with biofilm.

    6.  Neuroquant or Neuroreader volumetric analysis of the brain through MRI

    7.  Others

     

    E. Effective Options for Treatment/Management/Prevention:

    1. Supplements: vitamin B12 (especially methyl-B12, adenosyl-B12 or hydroxyl-B12 based on methylation cycle analysis), vitamin D, magnesium and minerals, curcumin (binds ribosomal sites that amyloid would like to bind),

    2. Dietary changes: Wheat, grain, sugar and dairy avoidance with high intake of good fats like fish, shellfish, nuts, seeds, avocadoes, coconut oil, bulletproof coffee (with brain octane oil and grass-fed butter), unicorn fuel coffee (with ceylon cinnamon, black pepper, turmeric, cayenne and coconut oil using frother) and others

    3. Lifestyle changes: Vigorous regular exercise, meditation, yoga, adequate sleep

    4. Infrared Sauna: increases BDNF and neurogenesis plus increases prolactin that helps with myelin production.

    5. Nasal antibiotic with EDTA, xylitol and/or nasal probiotics but with sinus rinse not neti pot.

     

    F. Bredesen Plan (with Lenhardt modifications)

    1.  Paleo diet or similar avoiding wheat, grains, dairy and processed sugar

    2. Fasting 12 hours each night between dinner and breakfast plus 3 hours between dinner and bedtime at a minimum to promote autophagy,

    3.  Stress Management through vigorous exercise, walking, meditation, yoga

    4.  Sleep: improved quality and quantity with magnesium glycinate or Sleep Remedy

    5.  Methylation cycle supplements individualized by testing

    6.  Omega 3s: EPA predominant fish oil or Omegaberry

    7.  Hormone balancing especially managing high cortisol (reduces BDNF),

    8.  Probiotic for brain [see Brainmaker],

    9.  Reduce A-beta with curcumin and/or ashwaganda,

    10. D3/K2 from Pure Encapsulations,

    11. Increase NGf with H. erinaceus [an edible mushroom] -- It has been reported that H. erinaceus promotes nerve growth factor secretion in vitro and in vivo. Nerve growth factor is involved in maintaining and organizing cholinergic neurons in the central nervous system or ALCAR [acetyl L carnitine] -- Acetyl-L-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor (NGF) binding.  acetyl-l-carnitine has protective effect on brain neurons and the liver.

    12. Provide synaptic structural components with citicoline, DHA;

    13. Antioxidants like Omegaberry, vit C, NAC (but need to know CBS status);

    14. Optimize mitochondrial function with CoQ10, ALA, resveretrol, others

    15. Increase SirT1 function with resveretrol

    16. Detoxify heavy metals especially mercury

    17. Raise NOS with BH4, L-arginine (Perfusia) and methylation cycle supplementation

    18. Consider prevegen for memory if high calcium on HTMA.  Keeps calcium out of the brain and only need it temporarily until calcium levels to normal.  Robert Thompson says that calcium supplements are contributing to dementia.

    19. Infrared Sauna: https://www.youtube.com/watch?v=aHOlM-wlNjM  Infrared sauna helps focus by increasing release and storage of norepinephrine and increases prolactin that helps brain function faster through myelination plus increases BDNF that increases growth of new brain cells and decreases depression and anxiety.

    20. Singing and Music Therapy through the SingFit phone App or other especially with songs popular from the ages of 12-18.

    21. Increase BDNF: 4-5 nutrients that increase BDNF to help cognition/memory: B12, zinc, magnesium, omega 3s and diet esp. nuts, oysters, mussels, seafood.  Estrogen and exercise increase levels of BDNF; stress and the stress hormone cortisol reduce levels.

     

    Simplified version:

    1. Basic standard dementia work-up including MRI brain (with assessment of calcification status, other) then…

    2. Rule out CIRS (with HLA DR DQB1, VIP, alpha-MSH and VCS) and Lyme (through Nanotrap, Western Blot and CD 57 panel) then…

    3. Paleo, Nutrient 950, Omegaberry, NAC, walking, fasting, singing and detoxifications plus 23andme/MTHFRsupport.com/ Prometheus

    4. Reassess and add other elements/supplements from list above

     

    G. References and Notes:

    1. Lyme:  both normal looking borrelial spirochetes and their encysted forms have been found in the amyloid deposits in Alzheimer’s Dementia (AD) patients.  Studies have shown that Bb will initiate amyloid deposits in the brains of test animals and amyloid seems to be a protective antimicrobial response in the brain. AD may be one possible outcome of a decades long borrelia infection.   Spirochetes were observed in the brain of more than 90% of AD cases. Miklossy (2004) study that spirochetes isolated from the brain tissue of people diagnosed with AD could be grown in a growth medium selective for Bb. "It appears that a number of "idiopathic" conditions such as AD are in fact the consequences of long-term bacterial and viral infections.

     

    2. Tryptophan: When tryptophan is degraded by certain enzymes, it is unavailable for serotonin production. Kynurenine is a byproduct of tryptophan breakdown so higher levels correspond to low tryptophan levels. Seen in those with depression, anxiety, Alzheimer’s and tic disorders.

     

    3. BDNF: 4-5 nutrients that increase BDNF to help cognition/memory: B12, zinc, magnesium, omega 3s and diet esp. nuts, oysters, mussels, seafood.  Estrogen and exercise increase levels; stress/cortisol reduce levels. Low BDNF associated with MDD, PTSD, AD, schizophrenia and proportional to severity of Alz. Dz.

     

    4. Gliadin causes increased gut permeability and more permeable blood-brain barrier.  Cyrex Array 2 measure lipopolysaccharide (LPS) Ab levels.  LPS is an endotoxin from Gram negative bacteria and induces a violent inflammatory response. Normally LPS is blocked by tight junctions. Causes learning deficits, beta amyloid build up. Alzheimer’s patients have 3x the LPS in blood. 2x for autism. LPS levels reduced by red wine.

     

    5. Genetics: ApoE4 especially and then APP, PSEN1 and PSEN2 also associated with Alzheimer's. NOS and others in methylation cycles with uncertain role. MTHFR A1298C: neurologic and mental health issues, low BH4, ? methylfolate levels -à more important to use krill oil (which is better for brain than fish oil)

     

    6. Urine OAT Test:  Stimulus for production of beta amyloid is bacteria and yeast (from antibiotics) via quinolinic acid increases (phthalates and quinollinic acid are same molecule except one nitrogen)

     

    7. Nitric Oxide Synthase (NOS): NOS converts L-arginine to L-citrulline and NOS.  There are three NOS isoforms, I, II and III and all require BH4, calcmodulin, O2, NADPH, FMN.  NOS problems are potentially associated with "hypoxic ischemic encephalopathy" Ammonia detox can be important: can use activated charcoal at bedtime, yucca with meals for that issue? NO Boost supplements like Neo40 from Genetics Based Integrative Medicine "BH4 produces NO to protect the brain" Ecological Formulas BH4 supplement 2.5mg but need a lot of vitamin C for it to work. Possibly get pure BH4 powder from Schircks in Switzerland?

     

    8. Iron overload:  “We are saying there is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component, and that this can be woken up by iron dysregulation. Removing this iron will slow down or prevent cognitive degeneration – we can’t keep ignoring all of the evidence,” Professor Douglas Kell said.

    From http://neurosciencenews.com/microbes-alzheimers-neurology-3826/

     

    9. SIBO: The microbial presence in blood may also play a fundamental role as causative agent of systemic inflammation, which is a characteristic of Alzheimer’s disease – particularly, the bacterial cell wall component and endotoxin, lipopolysaccharide. Furthermore, there is ample evidence that this can cause neuroinflammation and amyloid-β plaque formation.

  • Mental Health

    A. Key elements

    1. nutrition

    2. sleep

    3. stress management

    4. hormone balance

    5. detoxification

    6. methylation cycle anomalies

    7. gastrointestinal health and malabsorption

    8. neurotransmitter balancing

     

     

    B. Mainstream work-up: None

     

    Mainstream treatments: pharmaceuticals like SSRIs, SNRIs, mood stabilizers and benzodiazepines; psychotherapy and cognitive behavioral therapy (CBT)

     

    C. Resources:

     

    • A Mind of our Own by Kelly Brogan, MD book and her Vital Mind Reset program
    • Brainmaker by David Perlmutter, MD
    • The Hormone Cure by Sara Gottfried, MD
    • The Happiness Diet by Drew Ramsey, MD
    • Feel Good Nutrigenomics by Amy Yasko, ND, PhD
    • The Chemistry of Joy by Emmons
    • The Best of All Worlds by Andrew Lenhardt, MD

     

    D. Testing Options:

     

    1.  Blood Tests: RBC magnesium, RBC zinc, RBC folate, homocysteine, thyroid panel (TSH, free T4, free T3, reverse T3), free testosterone, estradiol, progesterone, DHEA, pregnenolone, morning cortisol level

    2.  Hair Tissue Mineral Analysis (HTMA) especially to check for mineral deficiencies and imbalances

    3.  Methylation cycle SNP analysis through 23andme and then geneticgenie.org, livewello.com or mthfrsupport.com

    4.  Salivary testing with 4 samples to check cortisol and assess adrenal status

    5.  Urine for Organic Acids especially to check: a. neurotransmitter metabolites and precursor levels; b. dysbiosis (imbalanced microbial flora), c. vitamin, mineral and nutrient deficiencies.

    6.  Sleep Analysis through sleep lab or phone App or other

    7.  GPL-Tox Screen

     

    E. Effective Options for Treatment/Management/Prevention:

     

    1.  Nutrition: avoid processed sugar; avoid processed foods (that tend to be high in glutamate), avoiding wheat/gluten (especially based on tests like haptoglobin genetic PCR test) and emphasize foods with high nutrient density.

    2.  Supplements: omega-3 fatty acids (Omegaberry, Nordic Naturals, others), curcumin (Curcuwin, Curcumasorb, others), 5-HTP (to raise serotonin levels), P5P and especially an individualized regimen of B-vitamins and minerals based on methylation cycle genetic SNP analysis and/or hair tissue mineral analysis (HTMA) and/or Urine OAT.

    3.  Stress Management: meditation, yoga, self-hypnosis, biofeedback, psychotherapy, cognitive behavior therapy, EMDR therapy (especially for post-traumatic stress disorder)

    4.  Sleep: sleep hygiene principles, melatonin, magnesium malate or glycinate, and/or the Sleep Remedy supplement through docparsley.com

    5.  SSRI medications like Celexa and Zoloft for chronic anxiety as an adjunct to other approaches but not as an isolated treatment

    6.  Infrared Sauna: increases relative endorphins and suppresses the negative dinorphins (more than exercise alone) and improves stress tolerance.

    7.  Regular Vigorous Exercise

    8.  Gut/Brain/Immune Axis Management of the Microbiome with prebiotics, probiotics, fermented foods, probiotic enemas and other modalities.

    9.  Bioidentical hormone regimens based on blood or saliva testing.

     

     

    F. Refences and Notes:

     

    1. From the book Brainmaker by David Perlmutter, MD: Five core probiotic species: l. plantarum, l acidophilus, l. brevis, b. lactis, b . longum and take orally or can use probiotic enema (p 211).  Enema bag, 3-6 probiotic capsules, filtered chlorine free water, -in morning, after bowel movement.  Fill large cup with 12 oz. lukewarm water.  Dump in probiotics, stir.  Fill enema bag.  Lie down on side in tub.  Hold bag higher than nozzle, release clamp.  Try to hold 30 minutes up to 3x weekly for 4-6 weeks!

     

    2. Tryptophan/Gut Health: When tryptophan is degraded by certain enzymes, it is unavailable for serotonin production.  Kynurenine is a byproduct of tryptophan breakdown so higher levels correspond to low tryptophan levels.  Seen in those with depression, anxiety, Alzheimer’s and tic disorders.

     

    3. GABA comes from glutamine and the cofactors zinc and B6.  Lactobacillus and bifidobacterium produce GABA in abundance thus the potential benefits of probiotics and improvement in gut health and microbiome for chronic anxiety.

     

    4. Dr. Lam notes on OAT Axis Imbalances and Management.

     

    5. Calcium Lie II Notes from Robert Thompson’s book.

     

    The most effective dose melatonin is 0.2mg or 200mcg under tongue or nasal spray rather than oral in dose range 2-10mg at bedtime.

     

    Low tryptophan causes or contributes to serotonin deficiency and is implicated in migraines, depression, anxiety and insomnia.  But never use typtophan supplements because can be shunted to quinolinic acid production which can contribute to ill health.  Can use 5-HTP instead to stimulate more serotonin production but this is better directed through testing like the Urine for organic acids (OAT).

     

    6. From AARM Conference September, 2016:

     

    a. dopamine: 1. contracts the colon in the gut so if low, people are often constipated and depressed.  2. Regulates the reward system; 3. If high, pleasure, motivated, creative -- if low, depressed -- if too high, mania and schizophrenia and stimulates ghrelin and that increases hunger

     

    b. serotonin: 1. regulates BMs, 2. low, anxiety but high libido and sleep with any MHC; high happy and positive but low libido and find opposite  MHC by smell.

     

    c. GABA: if low, leads to ADHD, depression; normal level, relaxation, focus and good sleep

     

    d. Brain research lecture from AARM:

     

    * degree of neurologic disease relative to cytokines IL-1 (depression), IL-6 (anxiety), TNF (hostility) that are pro-inflammatory

    * they studied “catastrophizers”:  when men are exposed to stress, IL-6 went up and then down to normal within 10 minutes; for women, it went up to a much higher levela over 6 hours before returning to normal.

    * microbiome is crucial relative to transient bacteria and permanent ones that are co-evolved.  1st wave is birth canal and if c-section, should do vaginal swab into babies mouth.  2nd wave is breastfeeding.  3rd wave is via food introduction.  bifidis bacteria regulate TGF-Beta response.  bacteroides is the poop smell, but can't increase with probiotic, need prebiotic.  bacteroides fragilis resolved OCD in mice.  lactobacillus increases gaba and reduces anxiety and depression in mice.  microbiome regulates gut permeability and blood-brain barrier.  microbes can make dopamine, serotonin and GABA.

     

  • Prepregnancy Planning

    A. Key Elements

    1. Nutrient analysis: 17% of children’s IQ can be attributed to mom’s omega-3 status.  Pregnant women need 7gm of minerals daily especially iodine (vs. 3gm for a non-pregnant adult)

    2. Food sensitivity testing

    3. Stress management

    4. Detoxification: children’s IQ potentially reduced by fluoride (up to 7 points), PAH (up to 4 points), lead (1.5 points), phthalates (up to 7 points) and organophosphates (up to 7) from in utero exposure.

    5. Genetic testing including methylation cycle SNP analysis, haptoglobin H2 status

     

    B. Mainstream

     

    Mainstream work-up beyond a history and physical: some basic laboratory tests, first trimester ultrasound

     

    Mainstream treatments: prenatal vitamins with folic acid

     

     

    C. Resources

    • The Calcium Lie II Youtube lecture or book by Robert Thompson, MD
    • Why Zebras Don’t Get Ulcers by Robert Sapolsky

     

     

    D. Testing Options (beyond standard prenatal testing)

     

    1.    Blood Test: RBC zinc, RBC folate, homocysteine, B12, methylmalonic acid, TSH, free T3, reverse T3, CMP, CBC

    2.    Hair Tissue Mineral Analysis (HTMA) to check for heavy metal toxicity and mineral deficiencies

    3.    GPL-Tox screen from Great Plains Laboratories that check for 150 different toxins

    4.    Home assessment including water analysis through a group like Biomarine in Gloucester.

    5.    Serum bromine level

     

    E. Options for Treatment/Management/Prevention

    1.    Supplements:

    a.    Methylfolate minimum of 400mcg per day (not folic acid) before conception.

    b.    Minerals: the average person needs 3gm of mineral per day but a pregnant woman needs 7gm per day especially iodine (to displace bromine, chlorine and fluoride) through I-throid or Iodoral plus Concentrace, Aussie Mineral drops, 40,000 volts mineral drops, Robert Thompson’s minerals  or other.   Can quantify iodine deficiency through the 24-hour urine iodine loading test.

    c.     Omega 3s at 2,000-3,000mg a day through Omegaberry, Nordic Naturals and others

    2.    Detoxification: individualized based on testing but to include glutathione, NAC, DMSA and other agents but also avoiding fluoride (toothpaste), chlorine (water), bromine (use King Arthur flour, careful with berries), plastics, lead and organophosphates.

    3.    Stress Management: yoga, meditation, therapy

     

     

    F. References and Notes

     

    1. From Brainmaker: OCPs if used more than 5 years: decrease thyroid hormone, deplete folate, decrease testosterone, increase insulin resistance and deplete vitamins, minerals and antioxidants.  Interfere with fertility.  Decrease libido and increase vaginal dryness.

     

    2. Robert Thompson has made claim 2016 that bromine is the primary cause of autism.

Protocols

Protocol Disclaimer: These notes are for reference only. They are works in progress and will be updated on a regular basis. Most treatment plans need to be individualized and each of these elements should be discussed with a physician or other qualified practitioner.

Please click on the protocol to learn more:

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